LOCUS       NM_003938               4950 bp    mRNA    linear   PRI 10-APR-2002
DEFINITION  Homo sapiens adaptor-related protein complex 3, delta 1 subunit
            (AP3D1), mRNA.
ACCESSION   NM_003938
VERSION     NM_003938.2  GI:20127437
KEYWORDS    .
SOURCE      human.
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Primates; Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 4950)
  AUTHORS   Simpson,F., Peden,A.A., Christopoulou,L. and Robinson,M.S.
  TITLE     Characterization of the adaptor-related protein complex, AP-3
  JOURNAL   J. Cell Biol. 137 (4), 835-845 (1997)
  MEDLINE   97296491
   PUBMED   9151686
REFERENCE   2  (bases 1 to 4950)
  AUTHORS   Ooi,C.E., Moreira,J.E., Dell'Angelica,E.C., Poy,G., Wassarman,D.A.
            and Bonifacino,J.S.
  TITLE     Altered expression of a novel adaptin leads to defective pigment
            granule biogenesis in the Drosophila eye color mutant garnet
  JOURNAL   EMBO J. 16 (15), 4508-4518 (1997)
  MEDLINE   97447555
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from AF002163.1.
            On Apr 10, 2002 this sequence version replaced gi:4501976.
FEATURES             Location/Qualifiers
     source          1..4950
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="19"
                     /map="19p13.3"
     gene            1..4950
                     /gene="AP3D1"
                     /note="ADTD"
                     /db_xref="LocusID:8943"
     CDS             312..3773
                     /gene="AP3D1"
                     /note="adaptin, delta"
                     /codon_start=1
                     /product="adaptor-related protein complex 3, delta 1
                     subunit"
                     /protein_id="NP_003929.2"
                     /db_xref="GI:20127438"
                     /db_xref="LocusID:8943"
                     /translation="MALKMVKGSIDRMFDKNLQDLVRGIRNHKEDEAKYISQCIDEIK
                     QELKQDNIAVKANAVCKLTYLQMLGYDISWAAFNIIEVMSASKFTFKRIGYLAASQSF
                     HEGTDVIMLTTNQIRKDLSSPSQYDTGVALTGLSCFVTPDLARDLANDIMTLMSHTKP
                     YIRKKAVLIMYKVFLKYPESLRPAFPRLKEKLEDPDPGVQSAAVNVICELARRNPKNY
                     LSLAPLFFKLMTSSTNNWVLIKIIKLFGALTPLEPRLGKKLIEPLTNLIHSTSAMSLL
                     YECVNTVIAVLISLSSGMPNHSASIQLCVQKLRILIEDSDQNLKYLGLLAMSKILKTH
                     PKSVQSHKDLILQCLDDKDESIRLRALDLLYGMVSKKNLMEIVKKLMTHVDKAEGTTY
                     RDELLTKIIDICSQSNYQYITNFEWYISILVELTRLEGTRHGHLIAAQMLDVAIRVKA
                     IRKFAVSQMSALLDSAHLLASSTQRNGICEVLYAAAWICGEFSEHLQEPHHTLEAMLR
                     PRVTTLPGHIQAVYVQNVVKLYASILQQKEQAGEAEGAQAVTQLMVDRLPQFVQSADL
                     EVQERASCILQLVKHIQKLQAKDVPVAEEVSALFAGELNPVAPKAQKKVPVPEGLDLD
                     AWINEPLSDSESEDERPRAVFHEEEQRRPKHRPSEADEEELARRREARKQEQANNPFY
                     IKSSPSPQKRYQDTPGVEHIPVVQIDLSVPLKVPGLPMSDQYVKLEEERRHRQKLEKD
                     KRRKKRKEKEKKGKRRHSSLPTESDEDIAPAQQVDIVTEEMPENALPSDEDDKDPNDP
                     YRALDIDLDKPLADSEKLPIQKHRNTETSKSPEKDVPMVEKKSKKPKKKEKKHKEKER
                     DKEKKKEKEKKKSPKPKKKKHRKEKEERTKGKKKSKKQPPGSEEAAGEPVQNGAPEEE
                     QLPPESSYSLLAENSYVKMTCDIRGSLQEDSQVTVAIVLENRSSSILKGMELSVLDSL
                     NARMARPQGSSVHDGVPVPFQLPPGVSNEAQYVFTIQSIVMAQKLKGTLSFIAKNDEG
                     ATHEKLDFRLHFSCSSYLITTPCYSDAFAKLLESGDLSMSSIKVDGIRMSFQNLLAKI
                     CFHHHFSVVERVDSCASMYSRSIQGHHVCLLVKKGENSVSVDGKCSDSTLLSNLLEEM
                     KATLAKC"
     misc_feature    402..2051
                     /gene="AP3D1"
                     /note="Adaptin_N; Region: Adaptin N terminal region"
                     /db_xref="CDD:pfam01602"
     variation       3525
                     /gene="AP3D1"
                     /allele="A"
                     /allele="G"
                     /db_xref="dbSNP:3189383"
BASE COUNT     1141 a   1440 c   1421 g    948 t
ORIGIN      
        1 ccaagcctga gtgttaattt aactctatgt tgtccgccgt gtaaacatcc gaggtcattt
       61 gttgcgttga attatctgac catccttttt tactgtgact cttcccattc tctttggcaa
      121 gaagtcccct tctcgccccc aaaccagcaa gggactcccc cacctgggtc tgtgccctgc
      181 cccgcgctgg gggccgagtc cttgaatgtg gcttcagggg ctcctgtcct gacggttgcg
      241 tccgggggag gggaaggaag ggccgctgtc gccaaggttt tctctcccag aacccacagt
      301 gggccgccgc gatggccctc aagatggtga agggcagcat cgaccgcatg ttcgacaaga
      361 atctgcagga cttggtccgc ggcatccgta accacaagga ggacgaggca aaatacatat
      421 ctcagtgcat tgatgagatc aagcaggagc tgaagcagga caacatagcg gtgaaggcga
      481 acgcggtctg caagctgacg tatttacaga tgttgggata cgacatcagc tgggccgcct
      541 tcaacatcat agaagtgatg agtgcctcca agttcacctt caagcgaatt ggctacctcg
      601 ctgcttccca gagctttcac gaaggcaccg acgtcatcat gctgaccacc aatcagatcc
      661 gtaaggactt gagcagcccc agccagtacg acacaggtgt tgcactgacg ggtctgtcct
      721 gcttcgtcac cccagacctt gccagagacc tggcaaatga catcatgaca ctgatgtcac
      781 acaccaagcc ctacatcagg aagaaggctg tgctgatcat gtacaaggtg ttcctgaagt
      841 accccgagtc gctgcgccct gcctttcccc ggctgaagga gaagctggag gaccccgacc
      901 ccggggttca gtcggctgcc gtcaatgtca tctgcgagct ggccagacgc aaccctaaga
      961 actacctgtc cctggccccg ctctttttca agctgatgac gtcctccacc aacaactggg
     1021 tcctcatcaa gatcatcaag ctgttcggtg ctcttactcc tttggaaccg cggctgggca
     1081 agaagctgat cgagcccctc accaatctca tccacagcac gtctgccatg tctctcctct
     1141 atgaatgtgt gaacaccgtg attgcagtgc tcatctcgct gtcctccggc atgcccaacc
     1201 acagcgccag catccagctt tgtgttcaga aattaaggat attgatcgag gactccgatc
     1261 agaacttgaa gtacctgggg ctgctggcaa tgtccaagat cctgaagacc caccccaagt
     1321 ccgtgcagtc ccacaaggac ctcatcctgc agtgcctgga cgacaaggac gagtccatcc
     1381 ggctgcgggc cctggacctg ctctatggga tggtgtccaa gaagaacctg atggagatcg
     1441 tgaagaagct gatgacccac gtagacaagg cagagggtac cacctaccgt gacgagctgc
     1501 tcaccaagat cattgacatc tgcagccagt ccaactacca gtacatcacc aacttcgagt
     1561 ggtacatcag catcctggtg gagctgaccc ggctggaggg cacacggcac ggccacctca
     1621 tcgccgccca aatgctggac gtggccatcc gcgtgaaggc catccgcaag ttcgccgtgt
     1681 cccagatgtc tgcgctgctt gacagtgcac acctgctggc cagcagcacc cagcggaacg
     1741 ggatctgtga ggtgctgtac gctgccgcct ggatctgcgg ggagttctca gagcatctgc
     1801 aggaaccaca ccacactttg gaggccatgc tgcggcccag agtcaccacg ctgccaggcc
     1861 acatccaggc cgtgtatgtg cagaacgtgg tcaagctcta cgcctccatc ctgcagcaga
     1921 aggagcaggc cggggaggca gagggcgctc aggccgtcac ccagctcatg gtggaccggc
     1981 tgccccagtt tgtgcagagc gcagacctgg aggtgcagga gcgggcgtcc tgcatcctgc
     2041 agctggtcaa gcacatccag aagcttcagg ccaaggacgt gcctgtggca gaggaggtca
     2101 gcgctctctt tgctggggag ctgaacccag tggcccccaa ggcccagaag aaggttccag
     2161 tccccgaagg cctggacctg gacgcctgga tcaatgagcc actctcggac agcgagtcag
     2221 aggacgagag gcccagggcc gtcttccacg aggaggagca gcggcgtccc aagcaccggc
     2281 cgtcggaggc ggacgaggag gagctggctc ggcgccgaga ggcccggaag caggagcagg
     2341 ccaacaaccc cttctacatc aagagctcgc catcgccaca gaagcggtac caggacaccc
     2401 cgggcgtgga gcacattccc gtggtgcaga ttgacctctc cgtccccttg aaggttccag
     2461 ggctgcctat gtcagatcag tatgtgaagc tggaggagga gcggcggcac cggcagaagc
     2521 tggagaagga caagaggagg aaaaagagga aggagaagga gaagaagggc aagcgccgcc
     2581 acagctcgct gcccacggag agcgacgagg acatcgcccc tgcccagcag gtggacatcg
     2641 tcacagagga gatgcctgag aatgctctgc ccagcgacga ggatgacaaa gaccccaacg
     2701 acccctacag ggctctggat attgacctgg ataagccctt agccgacagc gagaaactgc
     2761 ctattcagaa acacagaaac accgagacct caaaatcccc tgagaaggac gttcccatgg
     2821 tagaaaagaa gagcaagaaa cccaagaaga aagagaaaaa acacaaagag aaagagagag
     2881 acaaggagaa gaagaaggag aaggagaaga agaaatctcc caagcctaag aagaagaaac
     2941 acaggaagga gaaggaggag cggaccaaag gcaagaagaa gtccaagaag cagcctccag
     3001 gcagcgagga ggcagcgggg gagccggtgc agaatggcgc gccagaggag gagcagctcc
     3061 cgcctgagtc cagctactcc ctcctcgctg aaaattccta tgttaaaatg acctgtgaca
     3121 tccggggcag tctgcaggag gacagccagg tcactgtggc catcgtgctg gagaacagga
     3181 gcagcagcat cctcaagggc atggagctca gcgtgctgga ctcactcaat gccaggatgg
     3241 cccggccgca gggctcctcc gtccacgatg gcgtccccgt gcctttccag ctgcccccag
     3301 gcgtctccaa cgaagcccag tatgtgttca ccatccagag catcgtcatg gcgcagaagc
     3361 tcaaggggac cctgtccttc attgccaaga atgacgaggg tgcgacccac gagaagctgg
     3421 acttcaggct gcacttcagc tgcagctcct acttgatcac cactccctgc tacagtgacg
     3481 cctttgctaa gttgctggag tctggggact tgagcatgag ctcaatcaaa gtcgatggca
     3541 ttcggatgtc cttccagaat cttctggcga agatctgttt tcaccaccat ttttccgttg
     3601 tggagcgagt ggactcctgc gcctccatgt acagccgctc catccagggc caccatgtct
     3661 gcctcctggt gaaaaagggt gagaactctg tctcagtcga cgggaagtgc agtgactcca
     3721 cgctactgag caacttgtta gaagagatga aggcgacgct ggccaagtgt tgagagctgc
     3781 ctgcgagccc cgcaccaccc cgcggagcac gtacccaggg accgcagccc tgacgtgtct
     3841 cgcctctcct cagtcgtgtg tactgtaccc aagcctgagt gttaatttaa ctctatgttg
     3901 tccgccgtgt agacatccga ggtcatttgt tgcgttgaat tatctgacca tcctttttta
     3961 ctgtgactct tcccattctc tttggcaaga agtccccttc tcgcccccaa accagcaagg
     4021 gactccccca cctgggtctg tgccctgccc cgcgctgggg gccgagtcct tgaatgtggc
     4081 ttcaggggct cctgtcctgg gccagggcct gatgggcacc acgtgagggg cacttggtgg
     4141 acagggcggg gctgacgtgg cctcctctgg ggtcgcctgc ttttgaccca aaggtcctga
     4201 cggttgcgtc cgggggaggg gaaggaaggg ccgctgtcgc caaggttttc tctcccagaa
     4261 cccacagtgg gaaagcggtc ttgccaggcg ttgtccattg tcagtgtgct cgtgggctgg
     4321 tgactgggtc ttgggatccc aggccacgcg ccagccaggc tgtgggcagg gcggggccag
     4381 ggacgccaaa gagaggttgc agtcagaacc gtggacgggg tgggttgagg cctctctgcc
     4441 acccgtcttc ctggtcagca gaagtgcatc tcggcttggg tttggggtgg tccgcatccc
     4501 ctgcttgcca ctatgcgcac caaggtttcc ccacatcctt cccagcaccc ttaggaaggc
     4561 ccaggcaggg cctggaagca gcggacctgg gctgttctgt gttgaaggag tgtgcccagt
     4621 gcccttgggc aggacctgtg agagccacct cacaggcaga gcccccacca ggcagggcaa
     4681 ggagactccg ctcactcccc acggccagcg tgggcacagg actgaccctt cttcagagat
     4741 aatgacattt tatcttctcc ttttgatgaa aactgtcact ttagcatgta atccattaca
     4801 gaatcccatg cagtgattcc aggatttgaa attgtatgat gtgttacata agaatttatt
     4861 tgctatcgac attcccgtat aaagagagag acatatcacg ctgctgtcat gattttgtgt
     4921 caagatgatc caataaagtt gtaaaacagg 
//
