LOCUS       BC000578                1316 bp    mRNA    linear   PRI 12-JUL-2001
DEFINITION  Homo sapiens, hypoxanthine phosphoribosyltransferase 1 (Lesch-Nyhan
            syndrome), clone MGC:1722 IMAGE:3163726, mRNA, complete cds.
ACCESSION   BC000578
VERSION     BC000578.1  GI:12653602
KEYWORDS    MGC.
SOURCE      human.
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Primates; Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1316)
  AUTHORS   Strausberg,R.
  TITLE     Direct Submission
  JOURNAL   Submitted (15-NOV-2000) National Institutes of Health, Mammalian
            Gene Collection (MGC), Cancer Genomics Office, National Cancer
            Institute, 31 Center Drive, Room 11A03, Bethesda, MD 20892-2590,
            USA
  REMARK    NIH-MGC Project URL: http://mgc.nci.nih.gov
COMMENT     Contact: MGC help desk
            Email: cgapbs-r@mail.nih.gov
            Tissue Procurement: ATCC
            cDNA Library Preparation: Rubin Laboratory
            cDNA Library Arrayed by: The I.M.A.G.E. Consortium (LLNL)
            DNA Sequencing by: National Institutes of Health Intramural
            Sequencing Center (NISC),
            Gaithersburg, Maryland;
            Web site:       http://www.nisc.nih.gov/
            Contact:        nisc_mgc@nhgri.nih.gov
            Shevchenko,Y., Wetherby,K.D., Beckstrom-Sternberg,S.M.,
            Benjamin,B., Blakesley,R.W., Bouffard,G.G., Brinkley,C., Brooks,S.,
            Dietrich,N.L., Guan,X., Gupta,J., Ho,S.-L., Karlins,E., Legaspi,R.,
            Lim,M., Maduro,Q.L., Masiello,C., Mastrian,S.D., McCloskey,J.C.,
            McDowell,J., Pearson,R., Snyder,B., Stantripop,S., Thomas,P.J.,
            Tiongson,E.E., Touchman,J.W., Tsurgeon,C., Vogt,J.L., Walker,M.A.,
            Zhang,L.-H. and Green,E.D.
            
            Clone distribution: MGC clone distribution information can be found
            through the I.M.A.G.E. Consortium/LLNL at: http://image.llnl.gov
            Series: IRAL Plate: 5 Row: m Column: 19
            This clone was selected for full length sequencing because it
            passed the following selection criteria: matched mRNA gi: 4504482.
FEATURES             Location/Qualifiers
     source          1..1316
                     /organism="Homo sapiens"
                     /db_xref="LocusID:3251"
                     /db_xref="taxon:9606"
                     /clone="MGC:1722 IMAGE:3163726"
                     /tissue_type="Brain, neuroblastoma"
                     /clone_lib="NIH_MGC_19"
                     /lab_host="DH10B-R"
                     /note="Vector: pOTB7"
     CDS             49..705
                     /codon_start=1
                     /product="hypoxanthine phosphoribosyltransferase 1
                     (Lesch-Nyhan syndrome)"
                     /protein_id="AAH00578.1"
                     /db_xref="GI:12653603"
                     /translation="MATRSPGVVISDDEPGYDLDLFCIPNHYAEDLERVFIPHGLIMD
                     RTERLARDVMKEMGGHHIVALCVLKGGYKFFADLLDYIKALNRNSDRSIPMTVDFIRL
                     KSYCNDQSTGDIKVIGGDDLSTLTGKNVLIVEDIIDTGKTMQTLLSLVRQYNPKMVKV
                     ASLLVKRTPRSVGYKPDFVGFEIPDKFVVGYALDYNEYFRDLNHVCVISETGKAKYKA
                     "
BASE COUNT      408 a    215 c    278 g    415 t
ORIGIN      
        1 ggcacgaggc ctcctgagca gtcagcccgc gcgccggccg gctccgttat ggcgacccgc
       61 agccctggcg tcgtgattag tgatgatgaa ccaggttatg accttgattt attttgcata
      121 cctaatcatt atgctgagga tttggaaagg gtgtttattc ctcatggact aattatggac
      181 aggactgaac gtcttgctcg agatgtgatg aaggagatgg gaggccatca cattgtagcc
      241 ctctgtgtgc tcaagggggg ctataaattc tttgctgacc tgctggatta catcaaagca
      301 ctgaatagaa atagtgatag atccattcct atgactgtag attttatcag actgaagagc
      361 tattgtaatg accagtcaac aggggacata aaagtaattg gtggagatga tctctcaact
      421 ttaactggaa agaatgtctt gattgtggaa gatataattg acactggcaa aacaatgcag
      481 actttgcttt ccttggtcag gcagtataat ccaaagatgg tcaaggtcgc aagcttgctg
      541 gtgaaaagga ccccacgaag tgttggatat aagccagact ttgttggatt tgaaattcca
      601 gacaagtttg ttgtaggata tgcccttgac tataatgaat acttcaggga tttgaatcat
      661 gtttgtgtca ttagtgaaac tggaaaagca aaatacaaag cctaagatga gagttcaagt
      721 tgagtttgga aacatctgga gtcctattga catcgccagt aaaattatca atgttctagt
      781 tctgtggcca tctgcttagt agagcttttt gcatgtatct tctaagaatt ttatctgttt
      841 tgtactttag aaatgtcagt tgctgcattc ctaaactgtt tatttgcact atgagcctat
      901 agactatcag ttccctttgg gcggattgtt gtttaacttg taaatgaaaa aattctctta
      961 aaccacagca ctattgagtg aaacattgaa ctcatatctg taagaaataa agagaagata
     1021 tattagtttt ttaattggta ttttaatttt tatatatgca ggaaagaata gaagtgattg
     1081 aatattgtta attataccac cgtgtgttag aaaagtaaga agcagtcaat tttcacatca
     1141 aagacagcat ctaagaagtt ttgttctgtc ctggaattat tttagtagtg tttcagtaat
     1201 gttgactgta ttttccaact tgttcaaatt attaccagtg aatctttgtc agcagttccc
     1261 ttttaaatgc aaatcaataa attcccaaaa atttaaaaaa aaaaaaaaaa aaaaaa
//
